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When Trials Find Implausible Results—The SCOT-HEART trial

Sensible Medicine

An imaging test. One group of patients with chest pain received standard stress testing; the other received standard stress testing plus a coronary CT scan (CCTA). Here is the 5-year survival curves for the composite endpoint of CV death and MI: How can a diagnostic test lead to this much benefit? Not a drug.

Tests 306
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Nursing Quiz to Test Your Medical Skills

Scrubs

They carry out doctor’s orders, check up on patients throughout the day, and make sure providers have accurate information when looking at the patient’s chart. Nurses may need to refresh their memory of this knowledge every few years to make sure they have the latest and most up to date information. 34 12 votes, 1.9

Tests 244
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Race in Medicine

Sensible Medicine

In the years that followed, I learned of efforts to remove racial identifiers from medical textbooks and test questions. Race is a therefore terrible diagnostic test. We define diagnostic tests as tools that distinguish two populations, in medicine, diseased and healthy. We do this with BRCA testing.

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Sepsis Screening Decreases Mortality. Well, not really.

Sensible Medicine

If patient data tripped the alert, an EMR pop-up message would appear for nurses and physicians. These alerts were backed up with training and monitoring to encourage real action. Process measures suggested that doctors and nurses responded to the alerts with increased testing of lactate levels and fluid resuscitation.

Hospital 251
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Coronary Artery Calcium Trial Fails to Impress

Sensible Medicine

As a skeptic of this imaging test, I saw the headline and thought: finally, we will learn whether patients who have their chest radiated have better outcomes. Same with imaging tests. Trial Results After 3 years of follow-up, the CAC score-informed group showed significantly greater reductions LDL-C levels compared to usual care.

Tests 219
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A review of the newly approved novel non-opioid pain reliever suzetrigine (Journavx)

Sensible Medicine

A Google search brings up news releases from Vertex , and news coverage—which are essentially the same and lacking links to the evidence. The differences (from baseline) at each time are summed and weighted to come up the score. Last week the FDA approved a novel non-opioid pain medication. This was much more difficult to find.

Follow-Up 273
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I Am Afraid of Early Cancer Detection

Sensible Medicine

It’s been a few years since I first heard about the Galleri test produced by the Menlo Park startup Grail. Galleri is a blood-based screening test for cancer. For a couple of reasons, I didn’t work very hard to learn about the Galleri test. Second, I was worried that this test might have real promise.

Tests 363